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Oligonucleotide Chemist

Oligonucleotide Chemist

ComriseCambridge, MA, US
25 days ago
Salary
$90,000.00–$100,000.00 yearly
Job description

OLIGONUCLEOTIDE CHEMIST

Location : Cambridge, MA (Onsite)

Salary : $90K to $100k base

PRIMARY RESPONSIBILITIES :

  • Be responsible for the day-to-day work and management of the Oligonucleotide teams in Boston
  • Design and implement innovative strategies for the synthesis, purification, and scale-up of oligonucleotides
  • Utilize hands-on experience to optimize synthetic routes, purification methods, and bioconjugation protocols
  • Conduct analytical characterization using HPLC, LC-MS, and other analytical methods.
  • Complete the goals associated with specific oligonucleotide process optimization projects.
  • Develop solutions and provide recommendations as to the appropriate course of action to technical problems associated with the preparation of synthetic oligonucleotides.
  • Provides documentation and validation support in execution of synthesis and / or purification process changes.
  • Performs laboratory work and documentation in accordance with regulatory standards and company guidelines.
  • Mentor oligo team members, providing technical guidance and expertise in oligonucleotide chemistry

EDUCATION AND EXPERIENCE :

  • Minimum of a bachelor’s degree in Biochemistry, Chemistry, Molecular Biology or related discipline.
  • Minimum of 5 years of industrial or academic experience in the synthesis and purification of oligonucleotides.
  • Excellent understanding of the basic structure and function of DNA and RNA, including but not limited to advanced applications such as gene cloning and NGS preparation.
  • SKILL REQUIREMENTS : Competence & Skills

  • Experienced in high-throughput oligonucleotides synthesis, proficient in the operation of the 192&768 synthesizer, and carrying out simple instrument troubleshooting and repair.
  • Proficient in multiple analytical and purification techniques for DNA / RNA oligonucleotides to ensure that the purity and quality of oligonucleotides meet experimental requirements.
  • Experienced in the application of LC-MS technology for accurate qualitative and quantitative analysis of nucleotides.
  • Knowledge of commonly used biomolecular analysis methods (e.g. qPCR, DNA sequencing) or relevant practical experience.
  • Knowledge of the downstream application of oligonucleotides, like gene synthesis, molecular cloning, NGS, etc.
  • Professional Attitude

  • Good scientific thinking and innovation ability, able to independently design experimental programs and promote project progress.
  • Good teamwork spirit, able to communicate effectively with other researchers and solve research problems together.
  • Strong willingness to learn and ability to quickly adapt to new technologies and methods.
  • Welcome the challenge and extra responsibilities.
  • With clear career aspiration and willing to make impact to the environment
  • WORKING RELATIONSHIPS

  • Report to : Oligo Team Leader
  • You will be working with internal oligo team, as well as downstream gene synthesis, molecular cloning and NGS team at Boston