Our biotech client is expanding their world-class Antibody Engineering group and seeking an exceptional scientist with deep expertise in guided phage display and antibody discovery technology development. The Ideal Candidate Will Take On The Following Tasks Develop and advance next-generation phage display methodologies — including guided selection strategies, structure-informed panning, and epitope-directed approaches — expanding platform capabilities well beyond conventional campaign execution. Apply deep mutational scanning and NGS-based repertoire analysis to extract mechanistic insight, inform library design, and build predictive models of antibody fitness landscapes. Develop new phage display selection strategies for challenging targets such as membrane proteins and conformational epitopes. Shape intellectual property and advance the field through inventorship and high-impact publications. Partner with structural biology to leverage cryo-EM, crystallography, and molecular dynamics data to drive rational, structure-guided engineering decisions. Integrate AI/ML and computational tools into phage display workflows, leveraging generative protein design, protein language models, and in silico affinity prediction to accelerate lead identification and optimization. The Ideal Candidate Will Possess The Following Qualifications PhD in Molecular Biology or related field. Experience in sophisticated phage display with emphasis on method and technology development. High-impact publication record preferred. Desire to work at the interface of experimental and computational antibody engineering. #J-18808-Ljbffr
Senior Scientist, Antibody Engineering • Rockville, MD, United States
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