Senior / Principal Machine Learning Scientist

Senior / Principal Machine Learning Scientist

Our Mission

Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life.

Diversity at Altos

We believe that diverse perspectives are foundational to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment.

What You Will Contribute To Altos

As a Senior or Principal Machine Learning Scientist, you will play a prominent role in developing generative AI / ML models for multi-modal, multiscale biology from virtual cells to agentic target assessment. We are looking for a hands-on, creative, and collaborative individual to join our multidisciplinary team of scientists and engineers focused on transforming how we treat aging and disease. The successful candidate will thrive in a fast-paced environment that emphasizes teamwork, transparency, scientific excellence, originality, rigor, and integrity.

Responsibilities

Pioneer novel machine learning methodologies and statistical frameworks (e.g., generative models, causal inference, diffusion models, and advanced transformer architectures) to address fundamental challenges in cell health and rejuvenation

Contribute to setting the long-term technical vision and research strategy for a core domain (e.g., multi-modal data fusion, perturbation modeling) within the Institute of Computation

Translate your deep understanding of the mathematical and theoretical underpinnings of cutting-edge AI research into high-impact applications

Design, implement, and optimize large-scale machine learning systems using modern frameworks (e.g., PyTorch, JAX) and agile practices

Develop and manage efficient distributed training strategies across multiple GPUs and compute clusters to handle terabytes of multi-modal biological data

Develop robust approaches for multi-modal data integration and cross-domain mapping to extract actionable biological insights

Apply computational thinking to solve problems in drug target identification, compound assessment, and prediction of cellular perturbation responses

Lead the full ML development lifecycle from theoretical conception and data strategy through model development, training, and evaluation

Act as a key technical mentor to Machine Learning Scientists and Engineers, raising the bar for scientific rigor and model robustness across the organization.

Who You Are

Proven track record leveraging machine learning to solve real-world problems;

Expertise in one or more of the following : generative models, language models, computer vision, bayesian inference, causal reasoning & inference, transfer & multi-task learning, diffusion models, graph neural networks, active learning, cooperative agents

Experience writing production-quality code with modern machine learning frameworks such as PyTorch, TensorFlow, JAX, or similar

Experience with multi-GPU and distributed training at scale

A team player who thrives in collaborative environments and is committed to enabling colleagues to reach their full potential through giving and requesting feedback focussed on professional growth

Able to advise others across the wider function / company on cutting edge practices and approaches to enable the science / research. Desire to constantly expand your skillset and knowledge. Keen to learn more about biology, computational science, and medicine;

Inspired by the Altos mission of restoring cell health and resilience to reverse disease, injury, and age-related disabilities.

Minimum Qualifications

Ph.D. in Machine Learning, Computer Science, Artificial Intelligence, Statistics, or a related quantitative field, demonstrating a deep theoretical foundation in ML / AI.

6+ years of relevant post-PhD work experience in either an academic or industry setting

Proven experience developing and applying complex machine learning models, preferably with a significant portion of that time spent in a fast-paced industry or translational research environment.

A strong track record of leading and publishing innovative, peer-reviewed research in top-tier ML conferences (e.g., NeurIPS, ICML, ICLR) or high-impact scientific journals.

Excellent scientific communication skills : verbally and in writing; with computational and non-computational audiences, in informal 1-1 settings, team meetings, and formal seminars

Expertise in several of the following : deep learning, reinforcement learning, generative models, language models, computer vision, Bayesian inference, causal reasoning & inference, transfer & multi-task learning, graph neural networks, active learning, hybrid mechanistic / ML models

Proven experience applying sophisticated ML techniques to molecular and cell biological data sets (e.g., NGS, spatial omics, bioimaging).

Preferred Qualifications

Experience in cell health and rejuvenation related research area

Experience in the application of machine learning methods to biological data

Experience in computational approaches to drug discovery

Experience with software development methodologies and open-source software

The salary range for Redwood City, CA :

Senior Scientist I, Machine Learning : $ 280,500 - $379,500

Senior Scientist II, Machine Learning : $317,050 - $428,950

Principal Scientist, Machine Learning : $376,550 - $509,450

The salary range for San Diego, CA :

Senior Scientist I, Machine Learning : $ 260,950 - $353,050

Senior Scientist II, Machine Learning : $285,600 - $386,400

Principal Scientist, Machine Learning : $340,000 - $460,000

Exact compensation may vary based on skills, experience, and location.

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Equal Opportunity Employment

We value collaboration and scientific excellence.

We believe that diverse perspectives and a culture of belonging are foundational to scientific innovation and inquiry. At Altos Labs, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining an inclusive environment.

Altos Labs provides equal employment opportunities to all employees and applicants for employment, without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. Altos prohibits unlawful discrimination and harassment. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Thank you for your interest in Altos Labs where we strive for a culture of scientific excellence, learning, and belonging.

Note : Altos Labs will not ask you to download a messaging app for an interview or outlay your own money to get started as an employee. If this sounds like your interaction with people claiming to be with Altos, it is not legitimate and has nothing to do with Altos. Learn more about a common job scam at https : / / www.linkedin.com / pulse / how-spot-avoid-online-job-scams-biron-clark /

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