Department / Group : Chemistry
Location : South San Francisco, CA
Position Type : Full time
Role and Responsibilities
- Independently design synthetic strategies and use those strategies to synthesize and characterize precursor compounds, starting materials, intermediates, reference compounds, and new chemical entities
- Design small‑molecule drug candidates based on in vitro and in vivo biological activity, ADME / PK, physicochemical and IP‑relevant data.
- Purify and characterize molecules with standard analytical techniques (e.g. HPLC, LCMS, NMR)
- Use computation and structural data and information to design molecules
- Perform research and / or development in collaboration with others in chemistry and biology; make detailed observations and analyze data.
- Prepare batch records, technical reports, summaries, protocols and quantitative analyses
- Write and review manuscripts for publication
- Provide support in corporate research and development of patent applications
- Develop strategies to ensure effective achievement of scientific objectives
- Use skills to contribute to development of company objectives and principles and to achieve goals in creative and effective ways
- Exercise independent judgment in selecting methods, techniques and evaluation criteria for obtaining results
Qualifications and Education Requirements
PhD in Chemistry plus 5+ years of related experience in pharmaceutical or biotechnology industry or equivalent.Demonstrated expertise in synthetic organic chemistryMust possess expert knowledge of scientific principles and concepts.A solid understanding of modern analytical techniques (NMR, HPLC, MS)Excellent verbal and written communication skills and the ability to collaborate effectively within a multidisciplinary teamPreferred Skills
Experience in designing and synthesizing PROTACs or molecular glues is strongly preferredMolecular modeling and computational methodsAbility to manage outside vendor collaborationsFlexibility and willingness to solve problems that fall outside of immediate area of expertiseWork independently in an interdisciplinary, fast‑paced, often changing environment.Committed to the values of integrity, accountability, transparency, and drive.#J-18808-Ljbffr