Senior Scientist

Company Description

AI Therapeutics mission is to bring live-saving drugs to patients with rare diseases. AI Therapeutics is a rapidly growing health-tech company founded by award-winning scientist and highly successful serial entrepreneur, Dr. Jonathan Rothberg.

Joining AI Therapeutics is the opportunity to redesign the future of healthcare through the power of technology. Embark on a journey with us to maximize global impact, motivated by the idea that our products will change the lives of millions along with the people you love.

Job Description

We are seeking a candidate who is passionate about identifying and advancing novel drug candidates for rare disease. This individual will be highly motivated and use their basic and translational science expertise to interface with the research team and external partners to replicate in vitro model systems of disease to evaluate novel drug candidates and drug combinations, explore their mechanism of action and identify pharmacodynamic and patient selection biomarkers to implement in clinical studies. The candidate will also be enthusiastic about supervising and mentoring junior scientists.

As part of our team, your core responsibilities will be to:

• Independently lead rare disease translational sciences initiatives, working cross-functionally with preclinical and clinical teams to implement translational science strategies
• Demonstrate ability to design, execute, troubleshoot and interpret studies in model systems to validate new disease indications and identify potential pharmacodynamic and patient selection markers to support translational strategies for clinical development
• Work at the bench to develop and validate assays as well as train junior staff
• Identify and implement preclinical models to validate disease indications and biomarker strategies by developing external collaborations with academic institutions and CROs

Qualifications

Baseline skills/experiences/attributes:

• PhD in biochemistry, cell or molecular biology, pharmacology, medical science, or related fields
• Minimum of 2-5 years of related experience
• Solid understanding of model systems for dissecting disease biology including cell lines, primary cell cultures (including iPSC derived cells) and animal models – therapeutic area is not critical provided skills are adaptable to different tissue or cell models (e.g. oncology, CNS, pulmonary).
• Demonstrated expertise with in vitro and in vivo methods such as Western blotting, ELISA, next-generation sequencing, proteomic technologies, flow cytometry, etc., with the aim of developing assays to assess mechanism of action and biomarkers
• Previous industry experience (at least 2 years) and a solid understanding of the drug development process from lead identification through clinical trials are preferred
• The successful candidate will be highly motivated and able to work independently, able to work productively in a team environment and take ownership of multiple projects.
• Demonstrated ability in preparing technical reports, protocols, scientific portions of clinical documents and publications.

You Deeply Identify with Core AI Therapeutics Values:

• Efficient & Speedy - you get work done in a fraction of the time as industry peers
• Intellectually Curious - you are thoughtful & inquisitive; people enjoy working with you because they learn from you
• Mission-Driven & Committed - you are passionate about the company's purpose and are immensely productive
• Team Oriented - you celebrate and take joy in the success of others on the team
• Maintain highest ethical and technical standards

Additional Information

We offer great perks:

• Fully covered medical insurance plan, and dental & vision coverage - as a health-tech company, we place great worth on our teams’ well-being
• Competitive salaried compensation - we value our employees and show it
• Equity - we want every employee to be a stakeholder
• Pre-tax commuter benefits - we make your commute more reasonable
• 401k plan - we facilitate your retirement goals
• Beautiful office near the ocean-front in historic Guilford, Connecticut
• The opportunity to develop a revolutionary healthcare products and save millions of lives!