Principal Scientist / AD CMC Drug Substance

About GondolaBio

GondolaBio is a clinical-stage biopharmaceutical company focused on developing breakthrough therapeutics for genetic diseases. GondolaBio is an independent sister company to BridgeBio, originally carved out in 2024 after securing $300M in private financing from external investors. GondolaBio aims to leverage cutting-edge biological research to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases.

Who You Are

We are seeking an experienced and talented process chemist to lead process chemistry activities for a pre-IND small molecule. The Process Chemist will be responsible for developing, optimizing, and scaling synthetic routes for our clinical candidate. This individual will lead drug substance process development, including route scouting, lab-scale optimization, and technology transfer to CROs and CDMOs. The ideal candidate is a strong synthetic organic chemist with experience in process chemistry, scale-up, and external partner management.

Key Responsibilities

• Lead process development for the company’s oral small molecule drug substance.
• Design, evaluate, and optimize synthetic routes to improve yield, robustness, scalability, and sustainability.
• Perform route scouting and select optimal synthetic strategies for scale-up.
• Oversee process chemistry activities at CROs / CDMOs, including tech transfer, process optimization, and GMP manufacturing.
• Identify and mitigate potential scale-up risks (safety, quality, regulatory).
• Collaborate cross-functionally with internal teams (CMC, formulation, regulatory, program management).
• Prepare process development reports and regulatory documentation to support IND / clinical filings.
• Ensure alignment of drug substance process development with overall program timelines and milestones.

Education and Experience

No matter your role at GondolaBio, successful team members are

What We Offer

The base pay range for this position is $185,000 to $210,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered.

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