Talent.com
BostonGene
Scientist/Sr. Scientist - NGSBostonGene • Waltham, Massachusetts, US
No longer accepting applications
Scientist/Sr. Scientist - NGS

Scientist/Sr. Scientist - NGS

BostonGene • Waltham, Massachusetts, US
18 days ago
Job type
  • Full-time
Job description

About BostonGene

BostonGene is the developer of the leading AI foundation model for tumor and immune biology, a natively omnimodal platform designed to drastically accelerate and de-risk clinical trials. By integrating multidimensional clinical and biological data into a signal-stabilized, unified ecosystem, BostonGene’s foundation model provides unrivaled clarity across all stages of drug development.



The information below covers the role requirements, expected candidate experience, and accompanying qualifications.

Whether optimizing indication selection for early-phase programs, refining patient stratification for late-stage trials, or prioritizing evidence generation for post-market strategy, BostonGene enables smarter, faster clinical development informed by the unique biology of each drug.


Position Overview

BostonGene is seeking a bench Scientist to join our R&D next-generation sequencing (NGS) team in our laboratory located in Waltham, MA. This candidate will support assay development and technical transfer in collaboration with immunology, production, and bioinformatics teams. The candidate will be expected to support NGS protocols, such as RNA and DNA isolation from tissue, cell-free DNA isolation from plasma, library preparation, QC, and other lab processes. The role will primarily require laboratory bench work (70-80%) in a BSL-2 laboratory.


Key Responsibilities:

  • Perform assay and product development experiments of NGS workflows, including WGS, WES, and liquid biopsy assays for internal and external collaborators
  • Troubleshoot and support the technical transfer of workflows to the production lab.
  • Maintain detailed and accurate records in LIMS, ELN, and in compliance with laboratory protocols and regulatory requirements.
  • Assist in the development of laboratory SOPs and batch records.
  • Execute and assist with validation studies, bridging studies, and technical reports.
  • Stay informed on emerging technologies and trends in NGS to support innovation in assay development.


Qualifications:

  • Ph.D. in life sciences or related discipline with 0–3 years of relevant experience,

OR M.S. with 3–6 years,

OR B.S. with 6–10 years of hands-on experience.

(The job title will be commensurate with experience.)

  • Strong experience in nucleic acid extraction (DNA/RNA) from FFPE, blood, or other clinical samples.
  • Proficiency in NGS library prep (short-read and/or long-read), including WGS and WES.
  • Excellent problem-solving and troubleshooting skills.
  • Strong organizational skills with the ability to manage sample tracking, documentation, and inventory.


Preferred Skills & Experience:

  • Experience working with liquid biopsy samples (cfDNA/ctDNA, cfRNA, or exosomes).
  • Familiarity with NGS QC metrics and analysis tools.
  • Understanding of assay validation in regulated environments (GCLP, ISO).
  • Demonstrated experience in SOP development and process documentation.
  • Strong verbal and written communication skills, with the ability to work effectively in cross-functional teams.
  • Proven ability to work in a dynamic, fast-paced environment with shifting priorities.
  • Self-motivated and accountable, with a collaborative mindset. xgwfuhx


Additional Information

  • Ability to stand for prolonged periods and perform repetitive tasks inherent to laboratory work.
Create a job alert for this search

Scientist/Sr. Scientist - NGS • Waltham, Massachusetts, US

Similar jobs

Scientist

Careers Integrated Resources IncMassachusetts, United States
Full-time

Job Title: Scientist Job Location: Cambridge, MA Job Duration: 7 months (possible extension) Client name: Alnylam Pharmaceuticals Pay rate: $45/Hour on W2 Shift time : Standard Responsibilities: De... Show more

 • Promoted

Senior Research Scientist –Flammability and Fire Dynamics

FMNorwood, MA, United States
Full-time

Established nearly two centuries ago, FM is a leading mutual insurance company whose capital, scientific research capability and engineering expertise are solely dedicated to property risk manageme... Show more

 • Promoted

Scientist / Senior Scientist, Bioanalytical LC–MS – Oligonucleotide

Alloy TherapeuticsWaltham, MA, US
$126,000.00 yearly
Full-time
Quick Apply

Waltham, MA The Company We are Alloy Therapeutics -  a biotechnology ecosystem company empowering the global scientific community to make better medicines together.Through a community of partn... Show more

Nuclear Engineer

US NavyMansfield Center, MA, US
Full-time

Nuclear Engineer (Naval Reactors Engineer).Design, regulate, and oversee the Navy’s nuclear propulsion program, including reactor design, fleet operations, and eventual defueling and decommissionin... Show more

 • Promoted

Sr Metrology Technician

EDA StaffingMassachusetts, United States
Full-time

Metrology Quality Technician We’re looking for an experienced Metrology Quality Technician who knows precision measurement inside and out and takes pride in making sure parts are right the first ti... Show more

 • Promoted

NAVIGATION ALGO SFW ENG

GCR Professional ServicesMassachusetts, United States
Full-time

NAVIGATION ALGORITHM SOFTWARE ENGINEER Contract: 6-12+months 40 hours 9/80 Schedule REMOTE/HYBRID US Citizen with Active Secret Clearance Client is seeking an engineer with an M.Aerospace Engineeri... Show more

 • Promoted

Engineering - Assistant / Associate Scientist

EclaroMassachusetts, United States
Full-time

Engineering - Assistant / Associate Scientist Job Number: 26-00801 Be part of a company that delivers life-changing healthcare solutions.ECLARO is looking for an Engineering - Assistant / Associate... Show more

 • Promoted

MLS (Medical Lab Scientist) - SJH 0134

CharterCARE Health PartnersNorth Providence, Rhode Island, United States, 02911
Full-time
Quick Apply

MLS (Medical Lab Scientist) - SJH 0134.Under the direction of the Clinical Laboratory Supervisor, this position is responsible performing various chemical, microscopic, and or bacteriological tests... Show more

Principal Scientific Advisor (REMOTE)

Charles RiverWilmington, MA, United States
Remote
Full-time

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies.When you join our family, you will have a significant i... Show more

 • Promoted

CRNA Researcher

Yale New Haven HealthCumberland, RI, United States
Full-time

To be part of our organization, every employee should understand and share in the YNHHS Vision, support our Mission, and live our Values.These values - integrity, patient-centered, respect, account... Show more

 • Promoted

Scientist I (contract)

SanofiWaltham, MA, United States
Temporary

Sanofi's contingent workforce program, FLEXT Direct, is seeking a Scientist I for a 12 month contract.The Genomic Medicine Unit (GMU) in Sanofi is responsible for the design and optimization of cel... Show more

 • Promoted

CRNA

NewYork-PresbyterianCumberland, RI, US
Full-time

Amazing Patients, Inspiring Careers.Certified Registered Nurse Anesthetist - CRNA -NYP/Queens-.At New York-Presbyterian Queens Hospital, Certified Registered Nurse Anesthetists (CRNAs) deliver incr... Show more

 • Promoted

Scientist I or II, In Vivo Pharmacology, Drug Discovery

ALS TDIWatertown, MA, USA
$100,000.00 yearly
Full-time
Quick Apply

About the ALS Therapy Development Institute.The ALS Therapy Development Institute (ALS TDI) is the world's leading nonprofit biotech focused exclusively on discovering and developing effective trea... Show more

Cytotechnologist

CharterCARE Health PartnersProvidence, Rhode Island, United States, 02908
Full-time
Quick Apply

Under the direction of the Laboratory Manager the Cytotechnologist is responsible for the microscopic examination for cytologic diagnosis of GYN and NON-GYN samples.The Cytotechnologist performs pr... Show more

Senior Research Scientist – Fire Detection and Suppression

FMNorwood, MA, United States
Full-time

Established nearly two centuries ago, FM is a leading mutual insurance company whose capital, scientific research capability and engineering expertise are solely dedicated to property risk manageme... Show more

 • Promoted

(Senior) Principal Scientist, Cell Therapy

PharmaEssentia U.S.A.BEDFORD, MA, US
Full-time
Quick Apply

Senior) Principal Scientist, Cell Therapy Department: Cell Therapy/Innovation About the Role: We are seeking a Principal or Senior Principal Scientist to serve as a scientific cornerstone of our Ce... Show more

Evergreen Rising Stars in Scientific Computing

Flexcompute Inc.Watertown, MA, US
Full-time
Quick Apply

Flexcompute is a cutting-edge technology startup that specializes in ultra-fast simulation technology.Our products are utilized by companies in designing and optimizing technology products, with ap... Show more

Principal/ Senior Scientist – T Cell Engager & Multispecific Protein Engineering

PharmaEssentia U.S.A.BEDFORD, MA, US
Full-time
Quick Apply

Principal/ Senior Scientist – T Cell Engager & Multispecific Protein Engineering Position Overview PharmaEssentia is a global biopharmaceutical company dedicated to developing innovative ... Show more

Medical Lab Scientist/Technician, Lead - SJH

CharterCARE Health PartnersNorth Providence, Rhode Island, United States, 02911
Full-time
Quick Apply

Medical Lab Scientist/Technician, Lead - SJH.Under the general direction of the Manager, Laboratory Services is responsible for the delivery of quality, cost-effective laboratory services at Charte... Show more

Clinical Lab Scientist/Medical Technologist

Berkshire Medical Center, Inc.Massachusetts, United States
Temporary

NAME OF PETITIONER: Berkshire Medical Center, Inc.JOB TITLE: Clinical Lab Scientist/Medical Technologist WORKSITE ADDRESS: 725 North Street, Pittsfield, MA 01201 WAGE RANGE: $69,368.NUMBER OF HOURS... Show more