Senior Scientist, Biomarker Laboratory, Flow Cytometry and Immunoassay

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer. We are seeking a highly motivated and skilled Senior Scientist to join our Clinical Biomarker laboratory. This role will be responsible for the design, development, validation, and execution of flow cytometry and ligand‑binding assays (LBA) to support biomarker strategy and advance clinical drug development programs. The ideal candidate will have a deep scientific understanding of immunoassay platforms and hands‑on experience in developing and validating robust fit‑for‑purpose flow cytometric and LBA‑based biomarker assays as well as execute clinical sample analysis. Essential Functions of the job Serve as the lead scientist for the development, optimization and validation of flow cytometry assays (e.g. immunophenotyping, intracellular cytokine staining, receptor occupancy) and ligand binding assays (e.g. ELISA, MSD, ELISA, Luminex) for clinical biomarker analysis. Design experimental plans and lead execution of sample analysis to generate high‑quality and robust biomarker data. Collaborate with cross‑functional teams including translational science, clinical biomarker scientists, clinical biomarker operations and bioinformatics teams to ensure assay alignment with clinical objectives. Provide subject matter expertise in immune monitoring, pharmacodynamic and safety biomarker analysis; support multi‑disciplinary platforms (e.g. molecular assays) if needed. Author and review technical documentation including method validation and clinical sample analysis protocols, reports, and SOPs. Ensure quality control, data integrity, and timely delivery of analytical results. Maintain accurate lab records and mentor junior scientists. Supervisory Responsibilities This role is initially an individual contributor. May supervise lab scientists as the team grows. Computer Skills Proficiency in general software such as Microsoft Office (Word, Excel, PowerPoint), Outlook, Zoom, Teams as well as task‑related systems e.g. FlowJo, FACS Diva, Softmax. Other Qualifications Ph.D. in Cell Biology, Molecular Biology, Immunology, or related field with 3+ years or M.S. with 5+ years of relevant industry experience in a clinical, translational or regulated environment. Strong hands‑on expertise in multi‑parameter flow cytometry (e.g. BD FACSCanto, BD FACSymphony, Cyteck Aurora) including panel design, compensation, gating strategies and data analysis (FlowJo, FCS Diva, FCS Express). Experience with cell sorting is a plus. Demonstrated experience in ligand binding assay development using platforms such as MSD, ELISA, Luminex or Simoa. Proven track records in supporting clinical biomarker studies with demonstrated domain expertise and familiarity with relevant regulatory guidance for clinical assays to measure target engagement, receptor occupancy, immunophenotyping as well as pharmacodynamics endpoint. Strong analytical and problem‑solving skills with the ability to think critically. Excellent communication, organization and project management skills. Experience in lab automation, electronic laboratory notebook (ELN), laboratory information management system (LIMS) and initial lab workflow set‑up is a plus. Travel Under 10% Salary Range: $108,800.00 - $148,800.00 annually BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job‑related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process. Please note that the listed range reflects the base salary or hourly range only. Non‑Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness. We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact accommodationsus@beonemed.com. #J-18808-Ljbffr