Senior Research Associate, Functional Genomics & Cell Biology

Senior Research Associate, Functional Genomics & Cell Biology Our Mission Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. Diversity at Altos Altos Labs has been named one of the Top 3 Biotech Companies and ranked for the second year on the Forbes 2026 Best Startups in America list. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment. What You Will Contribute To Altos An exciting opportunity is available for a highly capable and motivated Senior Research Associate or Research Specialist to join Discovery Science at Altos Labs. We are seeking an outstanding experimentalist with strong technical depth in molecular biology, cell biology, and functional genomics who can operate with a high degree of independence and scientific rigor from day one. In this role, you will be a key contributor to the development and execution of discovery platforms that support target identification, mechanistic studies, and therapeutic validation. You will work at the interface of cell engineering, perturbation screens, and translational model systems, generating high-quality data in a fast-paced and deeply collaborative environment. This is an ideal opportunity for someone who thrives at the bench, takes ownership of complex workflows, solves technical problems proactively, and wants to help build next-generation approaches to reverse age-related disease. Key Responsibilities Independently maintain, expand, characterize, and troubleshoot a broad range of mammalian cell culture systems, including immortalized and primary cell models. Design and execute molecular biology workflows including cloning, plasmid construction, nucleic acid preparation, and RNA-based assays. Produce, optimize, and deploy viral delivery systems (including lentiviral and AAV platforms) for gene perturbation, expression, and cellular engineering studies. Perform CRISPR-based genome editing, pooled or arrayed perturbation workflows, and follow-up validation experiments. Develop, optimize, and execute robust cell-based assays, reporter systems, and phenotypic readouts. Support in vivo studies through mouse handling, tissue collection, tissue processing, and downstream molecular or cellular analyses as needed. Maintain exemplary documentation practices in ELN systems and help establish scalable SOPs and laboratory best practices. Demonstrated high productivity and ability to complete work in a timely manner. Who You Are BS or MS in Molecular Biology, Cell Biology, Biochemistry, Bioengineering, or a related discipline. 2+ years of relevant hands‑on experience in biotech, pharma, or leading academic laboratories. Proven strength in mammalian cell culture and execution of complex bench workflows with high reproducibility. Strong molecular biology experience, including cloning and nucleic acid‑based assays. Demonstrated experience with viral transduction, gene delivery, and/or genome editing platforms. Ability to independently troubleshoot experiments, manage multiple priorities, and deliver high‑quality work with speed and precision. Excellent organizational skills, clear communication, and strong ownership mentality. Preferred Qualifications Experience with primary human cells, stem cell systems, organoids, or other advanced cellular models. Experience with functional genomics approaches such as CRISPR screens, Perturb‑seq, or high‑throughput perturbation platforms. Experience with single‑cell and spatial omics platforms, including single‑cell RNA‑seq, single‑nucleus RNA‑seq, spatial transcriptomics, or related workflows. Experience with flow cytometry, imaging, high‑content screening, or automated cell analysis. Hands‑on experience with mouse handling and in‑vivo techniques, including tissue harvest, ex vivo culture systems, and familiarity with systemic delivery routes (e.g., AAV/LNP administration). Experience working with RNA workflows and delivery platforms. Strong interest in aging biology, regenerative medicine, or mechanisms of cellular rejuvenation. The salary range for Redwood City: Senior Research Associate: $109,200 - $140,000 Exact compensation may vary based on skills, experience, and location. Equal Opportunity Employment We value collaboration and scientific excellence. We believe that a culture of belonging is foundational to scientific innovation and inquiry. At Altos Labs, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining an inclusive environment. Altos Labs provides equal employment opportunities to all employees and applicants for employment, without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. Altos prohibits unlawful discrimination and harassment. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training. Thank you for your interest in Altos Labs where we strive for a culture of scientific excellence, learning, and belonging. Note: Altos Labs will not ask you to download a messaging app for an interview or outlay your own money to get started as an employee. If this sounds like your interaction with people claiming to be with Altos, it is not legitimate and has nothing to do with Altos. Learn more about a common job scam at https://www.linkedin.com/pulse/how-spot-avoid-online-job-scams-biron-clark/ #J-18808-Ljbffr