Senior Scientist II, Rheumatology

About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across key therapeutic areas including immunology, oncology, and neuroscience, as well as our Allergan Aesthetics portfolio. Senior Scientist II – Rheumatology Location: Cambridge Research Center (CRC) AbbVie’s Discovery Immunology R&D organization is seeking a highly motivated and innovative individual to support preclinical drug discovery programs in rheumatology, focusing on Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA). The role emphasizes target validation, mechanism‑of‑action studies, translational research, and advancement of novel therapeutic strategies. Key Responsibilities Serve as a functional representative responsible for setting Rheumatology strategy for pipeline programs and contributing to target evaluation and model development. Drive in vitro and in vivo pharmacology for drug candidates, including establishing PK/PD relationships, developing and optimizing screening assays, designing and executing mechanism‑of‑action studies, and evaluating candidate efficacy. Develop acute and/or chronic murine models of inflammation to support preclinical development of candidates for rheumatological and other autoimmune diseases. Apply immunological techniques such as flow cytometry, PCR/gene expression analysis, protein and cytokine quantification, histopathology, and other relevant functional readouts. Design experiments, analyze data, and present findings at AbbVie scientific forums and external conferences. Author and review technical reports, protocols, and other key scientific documents. Adhere to corporate standards related to code of conduct, documentation, safety, proper handling of materials, and humane treatment of laboratory animals. Qualifications Bachelor’s degree with 12+ years of experience, Master’s degree with 10+ years of experience, PhD with 4+ years of experience. Proven expertise in in vitro and preclinical in vivo model systems. Excellent interpersonal, communication, and collaboration skills. Ability to work effectively in a highly collaborative environment, including cross‑functional teams and colleagues across multiple locations. Prior experience in the pharmaceutical or biotechnology industry is preferred. Leadership Competencies Builds strong relationships with peers and cross‑functionally with partners outside of the immediate team to enable higher performance. Learns fast, grasps the “essence” and can change course quickly as needed. Creates a learning environment, open to suggestions and experiments to drive science in the field of interest. Embraces the ideas of others, nurtures innovation and manages innovation to reality. Compensation & Benefits Base pay range: as described at the time of posting, based on job grade; final compensation may vary. Benefits include paid time off (vacation, holidays, sick), medical/dental/vision insurance, and 401(k) for eligible employees. Eligibility for long‑term incentive programs. AbbVie is an equal‑opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, and serving our community. Equal Opportunity Employer / Veterans / Disabled. #J-18808-Ljbffr