Sr Manager, Operational Excellence- Manufacturing Process Improvement

Senior Manager Of Operational Excellence

Everyone at Kite is grounded by one common goal - curing cancer. Every single day, we seek to establish a direct line between that purpose and our day-to-day work. Would you like to join us in this mission?

Seeking a motivated leader with an Operational Excellence (OE) mindset to drive OE initiatives at our cancer immunotherapy viral vector manufacturing site in Oceanside, CA (MVP01). This role is part of the company-wide OE Network and will lead the development and implementation of OE programs across Technical Operations locally and throughout the network.

The OE Senior Manager plays a critical role in driving meaningful change by working directly with stakeholders, employees, and processes to embed a culture of excellence through hands on engagement and continuous improvement.

The Senior Manager demonstrates experience in applying continuous improvement techniques and producing results for functions, while assessing current business performance against Kite Pharma's business plan for a specific site and / or function. The Senior Manager partners with cross-functional teams to analyze findings, recommend improvements, and lead strategic continuous improvement initiatives. This role also trains staff and leaders to foster a culture of continuous improvement and reports to the Associate Director of Business Strategy & Operations. Please note : This an onsite role

Responsibilities of the Senior Manager of Operational Excellence include :

• Lead the development and execution of OE strategies to meet site goals, track progress, and escalate risks or barriers to success.
• Lead and coach teams in Lean methodologies including PDCA, DMAIC, root cause analysis, FMEA, Kaizen, and mistake-proofing.
• Develop strategic and tactical plans, KPIs, and dashboards to measure and advance MVP01's OE program.
• Build and maintain a pipeline of improvement initiatives through strong cross-functional partnerships across Manufacturing, F&E, Quality, Supply Chain, and MSAT.
• Translate operational requirements into actionable improvement plans, ensuring alignment with site and network goals.
• Identify and prioritize improvement opportunities by evaluating processes for waste, cost savings, benefit realization, complexity, and inefficiency.
• Ensure continuous improvement initiatives and site processes apply appropriate Lean / Six Sigma tools, track benefits, and celebrate success to reinforce a culture of excellence.
• Facilitate Lean leadership behaviors and daily management routines, including visual management and tiered accountability structures.
• Own and continuously improve the site's Tiered Meeting Structure, ensuring effective use of SQDEP metrics to drive performance, escalate issues, and foster accountability. Assess when changes are needed to enhance clarity, flow, and impact of tier meetings.
• Go to the work (Gemba) to observe, engage, and assess operational challenges firsthand, applying Lean principles to identify opportunities for efficiency, flow, and problem-solving. Guide teams in implementing practical solutions that align with OE best practices such as 5S / 6S, visual management, and standard work.
• Conduct Lean Maturity assessments and develop roadmaps for measurable improvement.
• Serve as a change agent by mentoring leaders and teams, fostering servant leadership, representing the site within the network, and driving adoption of OE principles.
• Build trust and credibility across all levels of the organization by demonstrating emotional intelligence, active listening, and a collaborative approach to problem-solving.
• Thrive in a dynamic, fast-paced manufacturing environment by managing multiple priorities, navigating ambiguity, and driving results under pressure.
• Ensure sustainability of OE initiatives by embedding problem-solving capabilities and Lean thinking into daily operations and team behaviors.
• Promote knowledge sharing and adoption of best practices across the site and broader manufacturing network.

Basic Qualifications :

Preferred Qualifications :

The salary range for this position is : $153,935.00 - $199,210.00. Kite considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans.