Associate Director, Project Management

Job Description

Job Description

About Summit :

Ivonescimab, known as SMT112, is a novel, potential first-in-class investigational

bispecific antibody combining the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule. Ivonescimab displays unique cooperative binding to each of its intended targets with multifold higher affinity when in the presence of both PD-1 and VEGF.

Summit has begun its clinical development of ivonescimab in non-small cell lung cancer (NSCLC), with three active Phase III trials :

• HARMONi is a Phase III clinical trial which intends to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who have progressed after treatment with a 3rd generation EGFR TKI (e.g., osimertinib).
• HARMONi-3 is a Phase III clinical trial which is designed to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.
• HARMONi-7 is a Phase III clinical trial which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC whose tumors have high PD-L1 expression.

Ivonescimab is an investigational therapy that is not approved by any regulatory authority in Summit’s license territories, including the United States and Europe. Ivonescimab was approved for marketing authorization in China in May 2024. Ivonescimab was granted Fast Track designation by the US Food & Drug Administration (FDA) for the HARMONi clinical trial setting .

Overview of Role :

The Associate Director of Project Management sits within the Program Management and Business Strategy department and is pivotal in contributing to a fit for purpose PMO and driving cross-functional execution and operational excellence across oncology development programs, particularly Phase 2 and beyond. The Associate Director will serve as a strategic integrator, aligning corporate and clinical development goals with functional execution across departments such as Clinical Operations, Development, Biometrics, Regulatory, Clinical Pharmacology, Biomarker Strategy, Bioanalytical, New Indication Planning, Quality, IT and Compliance.

This role will be responsible for building and refining infrastructure and processes that support scalable, transparent, and adaptive program execution. This includes dashboarding, process improvement and continuous monitoring to ensure visibility, accountability, and agility as the organization grows and our pipeline evolves.

Role and Responsibilities :

Develop integrated project plans, timelines, and templates from scratch tailored to program, cross functional, and governance needs.

Serve as a project management strategic liaison to 1–2 functional departments (e.g., Clin Ops, Biometrics, Clinical Quality, Clin Dev).

Design and implement scalable, adaptable processes that support program execution.

Develop and maintain dashboards using Smartsheets and other tools to track timelines, deliverables, and risks.

Navigate ambiguity with confidence and clarity.

Experience, Education and Specialized Knowledge and Skills :

Minimum of a Bachelor’s degree, preferably in a scientific or business discipline.

Minimum of 8+ years in a pharmaceutical company or CRO.

Proficiency in Smartsheets and dashboarding tools.

Effective leadership and team-building skills.

The pay range for this role is $153,000-$180,000 annually. Actual compensation packages are based on several factors that are unique to each candidate, including but not limited to skill set, depth of experience, certifications, and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus, stock, benefits and / or other applicable variable compensation.

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