Principal Product Manager, Prenatal

Ready to redefine what's possible in molecular diagnostics?

Join a team of brilliant, passionate innovators who wake up every day determined to transform healthcare. At BillionToOne, we've built something extraordinary—a culture where transparency fuels trust, collaboration drives breakthroughs, and every voice matters in our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we strive to build products that are 10x better than anything that exists today. Our people are our greatest asset : talented scientists, engineers, sales professionals, and visionaries united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion—every innovation you contribute helps remove fear of unknown from some of life's most critical medical moments. If you're driven by purpose, energized by innovation, and ready to help build the future of precision medicine, this is where you belong.

We are seeking an experienced Principal Product Manager, Prenatal to lead the product management efforts for our Unity product line, from EMR and digital experiences to clinical decision support tools. As the leader in product management, you will be responsible for the full product lifecycle from ideation and development to launch and growth for several key initiatives. The Principal Product Manager, Prenatal is a hybrid position (2-3 / week at our Menlo Park facilities) and reports to our Senior Director of Product. Fully remote candidates will not be considered.

If you are a passionate product leader with a proven track record in bringing innovative solutions  and data-driven products to the market, love collaborating with diverse groups, and thrive in a fast-paced environment, this is the perfect role for you.

Key Responsibilities :

• Product Strategy and Roadmap : Define and drive the product strategy and roadmap for the oncology product line, aligning with the company’s vision and business objectives.
• Product Development : Lead end-to-end product development, working closely with engineering, data science, and design teams to deliver high-quality products.
• Market and User Insights : Conduct market research and gather user feedback to inform product decisions and improve user experience.
• Stakeholder Collaboration : Collaborate with cross-functional teams and engage with healthcare professionals and pharma clients to incorporate feedback into product development.
• Go-to-Market Strategy : Develop and execute go-to-market strategies, creating compelling product positioning and messaging.

Requirements :

Benefits And Perks :

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary / equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package of $321,007 per year, including a base pay range of $197,676 - $218,484 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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About BillionToOne

BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA—a breakthrough that's already transformed the lives of over half a million patients worldwide.

Our Impact : We've pioneered game-changing diagnostic solutions that are redefining industry standards. Unity Complete™ stands as the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. In oncology, our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth : From $0 to $125 million in Annual Recurring Revenue in just four years. We've raised close to $400 million in funding, including a $130 million Series D round in June 2024, achieving a valuation of over $1 billion. This backing comes from world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition : Forbes recently named us one of America's Best Startup Employers for 2025 , and we were awarded Great Place to Work certification in 2024 —with an incredible 100% of our people reporting they are willing to give extra to get the job done . These honors recognize not just our innovation but the exceptional culture we've cultivated—one that remains authentically collaborative and transparent even as we've scaled.

Our Future : Headquartered in Menlo Park with facilities in Union City, California, we're continuing to push the boundaries of what's possible in molecular diagnostics. Recent clinical outcomes data for Unity Fetal Risk Screen and new advances in cancer diagnostics prove we're just getting started.

At BillionToOne, you'll join a diverse team of passionate innovators who believe that the best science happens when brilliant minds collaborate openly, think boldly, and never lose sight of the patients whose lives depend on our work.

Ready to help us change the world, one diagnosis at a time?

Learn more at www.billiontoone.com