Director Biostatistics Oncology (Statistical Science Lead)

Overview

Statistical Science Lead, Solid Tumor / Hematology (Director Biostatistics)

This position is based in Northbrook, Illinois. Remote work from certain states may be permitted in accordance with Astellas’ Responsible Flexibility Guidelines. Candidates interested in remote work are encouraged to apply.

This role is part of the Global Statistical Lead (GSTATL) within the Quantitative Science & Evidence Generation (QSEG) organization, accountable for driving the statistical and analytical strategy for a solid tumor compound or indication across its full development lifecycle. The GSTATL leads a cross-functional, integrated quantitative team supporting evidence generation and decision-making, spanning clinical trial statistics, exploratory statistics, medical affairs statistics, real-world evidence (RWE), safety / pharmacovigilance (PV) statistics, statistical programming, biomarker statistics, and advanced analytics.

The role ensures consistency and scientific excellence across studies, indications, and evidence types, while enabling innovation in statistical methodology, clinical development optimization, and external engagement. The GSTATL contributes to regulatory and payer strategy, internal governance, and portfolio planning for solid tumor assets.

Responsibilities And Accountabilities

Strategic Statistical Leadership

• Serve as the compound-level statistical lead for solid tumor oncology, responsible for end-to-end quantitative strategy supporting clinical development, evidence generation, and regulatory / payer interactions.
• Lead development of integrated statistical strategies across all relevant study types and functions (e.g., phase 1b / 2 signal-seeking, pivotal, exploratory, RWE, post-marketing).
• Align statistical and analytical approaches with the target product profile (TPP), development strategy, and external evidence needs.

Cross-Functional Quantitative Team Leadership

Regulatory and HTA Engagement

Innovation and Methodological Excellence

Mentorship and Capability Development

Governance and Cross-Functional Influence

Qualifications

Required

Preferred

Salary Range

$175K – $240K (NOTE : Final salary could be more or less, based on experience)

Benefits

EOE including Disability / Protected Veterans

Category

Quantitative Sciences & Evidence Generation

Astellas is committed to equality of opportunity in all aspects of employment.

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