In Vivo Scientist, Oncology

Job Description

Job Description

We are seeking an in vivo scientist who will design and execute in vivo studies of AAV-based cancer therapeutic candidates to advance our oncology pipeline and technology platform. You will contribute to preclinical study design and lead their execution, ensuring high levels of scientific rigor and compliance with relevant regulations. This is an ideal position for a candidate with a strong background in immuno-oncology and in vivo pharmacology who thrives in a team-oriented, cross-disciplinary collaborative environment.

Primary Responsibilities

• Design and execute preclinical in vivo studies in collaboration with discovery and data scientists, develop timelines and action plans to meet company goals.
• Choose appropriate in vivo models and develop protocols with relevant endpoints for evaluating the mechanism of action, efficacy, and safety of therapeutic candidates.
• Perform hands-on in vivo experiments, including orthotopic tumor cell implantation, IV, IP and SC injections, in vivo imaging, and animal welfare monitoring.
• Perform biological sample collection and processing, MACS / FACS cell sorting, immune cell profiling using multicolor flow cytometry, immunogenicity testing using ELISA and ELISPOT, and cell-based functional assays.
• Generate, document, analyze and interpret experimental data to support critical decisions.
• Manage external laboratories and partners.

Required Skills & Qualifications

At Pattern Bio, we design biological circuits at the intersection of synthetic biology and AI for cell-specific targeting of cancer tissue. By integrating data-driven design into every step—from DNA constructs to AAV-based delivery systems—we are building precise, rationally engineered, curative therapies. Our cohesive and driven team in South San Francisco is dedicated to curing cancer and saving lives.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.