Research Associate / Senior Research Associate Oligonucleotide Synthesis & Purification

Location : San Diego, CA

Seniority Level : Research Associate (RA) / Senior Research Associate (Sr. RA)

Employment Type : Full-time

About OliX Pharmaceuticals

OliX Pharmaceuticals is a clinical-stage biotechnology company developing next-generation RNA interference (RNAi) therapeutics. Our proprietary asymmetric siRNA (asiRNA) platform enables precise, durable gene silencing and supports delivery platforms such as GalNAc-asiRNA for liver-targeted therapies and cp-asiRNA for local delivery (skin, eye, lung). Active clinical programs and global partnerships (including Eli Lilly, LOral, and Hansoh Pharmaceutical) provide a strong foundation for discovery and development. By joining OliX, youll help shape the next generation of RNA medicines.

Role Summary

We are seeking a hands-on Research Associate / Senior Research Associate to support the synthesis, deprotection, purification, and analysis of chemically modified oligonucleotides that enable OliXs RNAi pipeline. You will operate and maintain key instrumentation (e.g., HPLC / UHPLC, preparative LC, TFF, UVVis), document work in SOPs, batch records, and reports, and collaborate closely with RNAi chemistry, medicinal chemistry, and biology teams to advance discovery and preclinical programs.

Key Responsibilities

• Execute (or Help) solid-phase oligonucleotide synthesis (SPS) and downstream processing (cleavage, deprotection, desalting).
• Purify and polish oligonucleotides using OPC, analytical and preparative HPLC / UHPLC, and UPLC; perform buffer exchange and concentration via TFF.
• Develop and optimize purification methods and in-process controls to improve yield, purity, and throughput.
• Perform analytical characterization (UHPLC / LCMS, UVVis); compile CoAs, batch records, and data summaries.
• Operate, maintain, and troubleshoot lab instruments; coordinate vendor service when needed.
• Author and revise SOPs, work instructions, and technical reports; ensure data integrity and traceability.
• Work cross-functionally with medicinal chemistry and biology teams to align materials specifications and timelines.
• Maintain safe, compliant laboratory operations and good housekeeping (5S); participate in EHS initiatives.
• (Sr. RA) Mentor junior team members; lead small method-development or process-improvement projects.

Qualifications

Required (RA) :

Required (Sr. RA) :

Preferred (both levels) :

Why Join OliX

Work Environment

OliX Pharmaceuticals is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.