Director, Compliance Operations

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) a serious liver disease that can progress to cirrhosis liver failure need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose : leading the fight against MASH.

Madrigals medication Rezdiffra (resmetirom) is a once-daily oral liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic inclusive and high-performing culture that values scientific excellence operational rigor and collaboration. To support our continued growth we are strengthening our workforce strategy to ensure we have the right talent at the right time in the right way.

Job Summary :

The Director Compliance Operations is a key strategic and operational leader responsible for driving the execution and continuous enhancement of Madrigals enterprise Compliance Program. This individual serves as a cross-functional business partner embedding compliance principles into business operations while enabling proactive risk mitigation and regulatory readiness.

This role balances hands-on program execution with leadership-level responsibilities contributing to long-term functional strategy influencing key stakeholders and shaping compliance infrastructure to scale with the organizations growth. The ideal candidate brings deep pharmaceutical compliance expertise a collaborative mindset and the ability to lead initiatives in a fast-paced evolving environment.

Key Responsibilities

• Lead the development implementation and continuous improvement of compliance operations infrastructure that supports a strong ethical culture across the organization.
• Serve as a strategic partner to business functions translating complex regulatory requirements into actionable risk-based compliance solutions.
• Oversee the management optimization and adoption of compliance tools dashboards and reporting systems to monitor program effectiveness.
• Facilitate Executive Level Contributions Review Committee meetings including agenda planning tracking action items and synthesizing outcomes for executive visibility.
• Collaborate with Legal Medical Commercial and other stakeholders to review assess and document high-risk activities (e.g. HCP engagements sponsorships advisory boards).
• Provide direction for the development and dissemination of compliance policies SOPs and guidanceensuring alignment with regulatory expectations and business needs.
• Design and deliver targeted role-specific compliance training and communications that support awareness accountability and behavioral change.
• Support enterprise risk assessment processes including data analysis stakeholder engagement and remediation tracking.
• Analyze outcomes from audits investigations and monitoring activities identifying themes and advising on continuous improvement opportunities.
• Stay abreast of evolving healthcare laws regulations and enforcement trends (e.g. OIG DOJ PhRMA state-level requirements); apply insights to refine program elements.
• Build relationships and influence across functions to embed compliance into strategic and operational planning.
• Lead or contribute to enterprise-wide compliance projects workstreams and systems implementations as needed.

Qualifications : Education

Experience

Madrigals Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance we empower employees to think like owners giving them a stake in the organization.

All employees receive equity which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidates qualifications skills education experience business needs and market demands. The base salary range for this position is $207000 to $253000 per year.

All full-time employees receive equity which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance we empower employees to think like owners giving them a stake in the organization.

Full-time employees are also eligible for comprehensive benefits including flexible paid time off medical dental vision and life / disability insurance and 401(k) offerings (i.e. traditional Roth and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance legal services and other addition we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal state and local laws.

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance please contact

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications merit and business need. Applicants will receive consideration for employment without regard to race ethnicity color religion sex gender identity sexual orientation national origin age disability protected veteran or disabled status or other characteristic protected by applicable federal state or local law.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals Hiring Managers seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigals name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g. fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.

Please also note that any correspondence with regard to employment would come from an authorized email address or from an email address from one of our trusted search firm partners. We are aware that incorrect / fraudulent email addresses with Madrigal misspelled have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal we recommend that you : do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to .

Required Experience :

Director

Key Skills

Employee Relations,Employee Evaluation,Management Experience,Profit & Loss,Conflict Management,Operations Management,Project Management,Budgeting,Leadership Experience,Supervising Experience,Leadership management,Financial Planning

Employment Type : Full-Time

Experience : years

Vacancy : 1

Yearly Salary Salary : 207000 - 253000