Vice President, Antibody Discovery and Engineering
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BigHat Biosciences designs safer, more effective biologic therapies for patients using machine learning and synthetic biology. BigHat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies.
About the Role
We are seeking a highly experienced individual for a position as Senior Director / Vice President of Antibody Discovery and Engineering. This position will report to the Chief Executive Officer and will be responsible for driving strategy for antibody discovery, design, optimization and characterization of antibody-based therapeutics, including multispecifics and other advanced modalities.
Responsibilities
- Lead External Programs function, and manage a team of scientists working on BigHat’s partnered therapeutic programs
- Serve as a scientific leader of discovery and optimization efforts at BigHat, guiding teams to best leverage experimental and computational differentiators of the Milliner platform across all therapeutic and partnered programs
- Drive innovative antibody technologies that advance therapeutic pipelines and that expand BigHat’s ability to design and optimize differentiated therapeutics
- Work closely with scientists and leaders in DS / ML, Protein Sciences, and Platform groups to ensure program teams are collaborating effectively towards clinic-ready therapeutics
- Be a thought leader in developing novel approaches for the discovery and optimization of antibody therapeutics for BigHat’s internal pipeline and partnered antibody therapeutics
Qualifications
Ph.D. in molecular biology, biochemistry, or related discipline, plus >15 years’ experience in antibody and protein engineering within the academic or biopharma / biotech sectors
10 years managerial experienceExtensive experience in antibody discovery using both in vivo and in vitro approachesProficiency with various protein display systems, such as yeast, bacteria, phage, and mRNA displaySkilled in library creation, selection, and enrichment analysisDeep knowledge of antibody structure function relationships and awareness of computational and / or machine learning-based approaches to discover and optimize proteins, including utilization of protein design toolsDeep expertise in biologics discovery and optimization from discovery to pre-INDExperience working with diverse antibody formats such as complex multispecifics, T-cell engagers, antibody fragments, antibody-drug conjugates, etc.Strong strategic vision and experience in developing and executing strategic plans aligned with organizational goalsAccountable, meticulous with attention to detail, and able to multitaskStrong teamwork and proactive communication skillsSelf-motivated and able to work independently in a cross-functional team environmentMust be willing to work onsite 5 days a weekPay range and compensation package
The salary estimated for this position is $250,000 - $300,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
What BigHat Offers :
Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)Dental, and vision coverage through GuardianAdditional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more401(k) with company matchDTO, two weeks of company-wide shutdown, and 12 company holidaysPaid parental leaveEqual Opportunity Statement
BigHat is committed to diversity and inclusivity.
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