Scientist, R&D Chemistry, Peptidomimetic Synthesis

Scientist (Peptidomimetic Synthesis), R&D Chemistry We are currently seeking a lab‑centric peptide chemist to join the R&D Chemistry group. You will play a key role in Regeneron's peptidomimetic antibody‑conjugate drug discovery capabilities, enabling seamless combination with our existing expertise in biologics and novel genetic medicines. The candidate will drive the synthesis and discovery of peptidomimetic payloads and linker payloads for antibody conjugate drug therapeutics across diverse research areas. Responsibilities Actively participate and collaborate in the day‑to‑day activities of the R&D Chemistry Peptidomimetic group. Perform medicinal chemistry inspired and SAR‑driven synthesis of novel peptidomimetic drug modality payloads/linker payloads, using modern peptide synthesizers and characterization instrumentation. Troubleshoot and optimize peptide potency and stability using standard peptide‑based principles (e.g., Ala scans), non‑natural amino acid incorporation, α‑Me/N‑Me peptide backbone modifications, and other medicinal chemistry strategies guided by in vitro assays, plasma/serum stability, and met ID data. Participate in R&D Chemistry Peptidomimetic efforts on internal/external project teams, and demonstrate the ability to multi‑task and parallel process to add to our continuous pipeline of Regeneron peptidomimetic conjugates. Identify new strategies and technologies to improve existing Regeneron platforms for pursuing novel synthesis of peptidomimetic drug modality conjugates. Actively participate in departmental, cross‑functional, leadership, and external meetings to contribute expertise and to represent the vision of the R&D Chemistry Peptidomimetic group. Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations. Qualifications Bachelor’s degree required, Master’s degree preferred in peptide/peptidomimetic and/or synthetic organic chemistry (or related). Extensive hands‑on experience in the synthesis and reaction troubleshooting of peptidomimetics, and extensive experience running modern synthesis, isolation, and characterization equipment. Expertise in modern methods of peptidomimetic synthesis and analytical characterization, and a minimum of 5‑10 years of industry experience. A track record of success in the field of either peptidomimetics or small molecules is required. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief, sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship. Salary range: $93,900.00 – $153,300.00 annually. #J-18808-Ljbffr