Gene Editing Off-Target Safety Lead; Lilly Genetic Therapies

JOB DESCRIPTION

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Gene Editing Off-Target Safety Lead; Lilly Genetic Therapies

Eli Lilly and Company is seeking a Editing Off-Target Lead to join our in Boston, MA.

Come join the rapidly expanding Gene Therapy team at Eli Lilly! We are responsible for inventing, characterizing, and advancing novel genome editing reagents for a myriad of clinical applications. Our team works cross-functionally within our organization across multiple disease areas and platforms. Our goal is to deliver on the promise of gene editing to patients around the world.

Job Responsibilities :

• Develop and execute strategic vision for gene editing safety characterization for multiple programs and serve as subject matter expert on gene editing safety for internal and external stakeholders.
• Establish clear data delivery timelines and quality standards for off-target characterization supporting regulatory submissions.
• Oversee implementation and optimization of IND enabling off-target quantification methods (GUIDE-Seq, UdiTaS, SITE-Seq, ITR-Seq, ONE-seq, etc…) across multiple programs.
• Lead and mentor the Off-target Team and work with a cross-functional team of scientists and engineers spanning, translational gene editing, off-target biology, NGS technologies, and laboratory automation to support the gene editing off-target safety strategy.
• Develop and execute strategic vision for gene editing safety characterization work flows and help establish high-throughput automation capabilities.
• Drive R&D initiatives to incorporate novel assays and emerging technologies into the gene editing pipeline.
• Deliver clear communication of technical capabilities, timelines, and results to diverse stakeholders and executive leadership.
• Support business development activities and external partnerships as needed
• Champion continuous improvement, operational excellence and documentation practices.

Job Requirements :

Additional Skills / Preferences :

Additional Information :

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include : Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$163,500 - $281,600

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and / or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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