Biologist

Biologist III

1 Year

Worcester, MA

About the Job

• The Bioprocess Development and Launch Department at the Bioresearch Center in Worcester, MA is seeking a highly motivated molecular biologist to join the CHO Cell Line Development team and advance the Biologics pipeline.
• The scientist in this position will have several responsibilities in supporting CHO biologics pipeline, including genetic characterization of cell lines and cell banks.

A strong candidate will have in-depth experience with a variety of molecular biology techniques and mammalian cell culture / aseptic technique, as well as exceptional attention to detail, demonstrated skills and productivity in laboratory research, and strong writing and communication skills.

Key Responsibilities :

• Characterize CHO cell lines using molecular biology techniques, including qPCR, ddPCR, Southern blot, and northern blot
• Sanger sequencing analysis
• Design of primer / probe reagents for gene copy number analysis
• Use of gel and blot imaging instruments
• Maintain detailed, accurate, and clear documentation of experiments and activities
• Effectively organize and communicate research progress and planned activities through oral and written presentations
• Collaborate with colleagues in the Cell Line Development group and across multiple functional areas of the Bioprocess Development and Launch department to advance the company Biologics Pipeline
• Maintain a high level of productivity in the lab
• Demonstrate scientific initiative and creative thinking to achieve project goals and contribute team performance in a climate of scientific rigor
• Contribute to the smooth and effective operation of the CHO Cell Line Development labs through the 5S program
• Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, and GxP compliance

Qualifications :

Bachelor’s Degree or Master’s Degree in Cell / Molecular Biology or a related field with 5 years of relevant experience;

pharmaceutical industry experience is preferred

• Expertise in molecular biology techniques, including DNA / RNA extraction and quantification, PCR-based assays, gel electrophoresis, blotting techniques and sequencing analysis
• Hands-on experience with mammalian cell culture
• Experience with DNA sequence manipulation software and common software packages such as Microsoft Office
• Excellent written and interpersonal communication skills with the ability to build strong relationships with peers and cross-functional team members
• Strong planning, multitasking, time management, and troubleshooting skills
• Collaborative and proactive attitude with strong scientific curiosity, work ethic, and attention to detail
• Authorization to work in the United States is required

Preferred Qualifications :

• Experience with expression vector elements, construction, and molecular cloning
• Experience with digital PCR assays, such as droplet digital PCR (ddPCR)
• Proven track record in vector biology, cell line genetic characterization, and / or CHO cell line development
27 days ago