Controller

Company Overview Mosaic Biosciences is a discovery and preclinical development company that partners with biopharmaceutical companies to discover novel protein and antibody therapeutics.

Our experienced and dedicated research teams collaborate with our partners to design, manage, and execute research programs to rapidly advance clinical candidates, starting at any point from early discovery into preclinical development Position Overview Mosaic is seeking a strategic, hands-on Controller to lead and scale our accounting and financial operations as we continue to grow.

The Controller will serve as a key member of the Finance leadership team, working closely with the CFO to provide financial insight, operational excellence, and strategic guidance that supports Mosaic’s continued expansion.

This individual will oversee all accounting functions, implement scalable systems and processes, and play a central role in financial strategy, reporting, and cross-functional decision-making.

Key Responsibilities Accounting Operations Oversee all accounting activities, including general ledger, accounts payable, accounts receivable, payroll, and expense reporting.

Ensure timely and accurate monthly, quarterly, and year-end close processes.

Maintain and improve internal controls, accounting policies, and procedures.

Financial Reporting Lead the preparation, analysis, and presentation of financial statements, management reports, and key business metrics.

Assist in the company’s financial forecasting, annual budgeting, and multi-year planning processes, collaborating with department leaders to align with strategic objectives.

Support preparation for external audits and liaise with external auditors.

Provide proactive financial analysis and insights to inform decision-making, optimize cost structures, and support company growth.

Compliance and Process Improvement Ensure compliance with GAAP and applicable federal, state, and local regulatory laws and rules.

Support the evaluation, selection, and implementation of enterprise financial systems (ERP, Procurement, and Project Management) to enable automation, scalability, and data integrity.

Evaluate and implement process improvements to increase efficiency within the accounting function.

Support cross-functional and company-wide process improvement initiatives.

Maintain documentation of policies, processes, and controls.

Business Partnership Work closely with the CFO to provide financial and business insights supporting Mosaic’s operational and strategic goals, including key financial drivers, P&L trends, client / project profitability, and cost optimization, Partner with department leaders to align budget management and expense tracking with project and business objectives.

Serve as a strategic thought partner to the executive leadership team in financial governance, resource allocation, and long-term planning.

Contribute to investor, audit, or due diligence activities as needed.

Qualifications Bachelor’s degree in Accounting, Finance, or a related field; CPA required. 8-10+ years of progressive accounting and finance experience, including 3–5 years in a Controller or senior accounting leadership role.

Proven experience leading accounting and financial operations in a growth-stage or complex organization; prior biotech or life sciences industry experience strongly preferred.

Deep understanding of GAAP and financial reporting requirements.

Experience with accounting software and systems (e.g., QuickBooks, Expensify).

Strong analytical and problem-solving skills with high attention to detail.

Excellent communication and interpersonal skills, with the ability to collaborate across teams and explain financial concepts to non-finance colleagues.

Ability to manage multiple priorities in a fast-paced, mission-driven environment.

Location :

• On-site – 5710 Flatiron Parkway, Boulder, CO 80301 Department : Finance Reports to : Chief Financial Officer Compensation : $150,000 - $180,000   Powered by JazzHR