Animal scientist Jobs in Indianapolis, IN

We’re looking for people who are determined to make life better for people around the world.

Lilly Neuroscience is seeking a dedicated scientist to join Neuroscience Discovery / Neurodegeneration Group to facilitate its mission of discovering novel medicines for the treatment of Alzheimer’s disease, Parkinson’s disease, and other related neurodegenerative conditions. You will contribute to research focused on developing therapeutics in close collaboration with other Neurodegeneration laboratories as well as Lilly’s chemistry and biotherapeutic engineering divisions. A substantial focus of the role will be the supporting development and implementation of in vitro / in vivo blood brain barrier (BBB) receptor-mediated transport models for protein and oligonucleotide based therapeutics. Do you possess hands-on laboratory experience, a keen interest to understand the molecular and cellular mechanisms that underlie non-invasive drug delivery to the CNS, and have an outstanding attention to scientific detail? This role would be a great fit.

Key Objectives :

• Develop primary neuron and primary microglia cell culture assays to understand receptor targeted drug efficacies in vitro and ex vivo.
• Routinely perform RT-qPCR and ELISA assays to assess PKPD target engagement and efficacy of systemically administered antibody drug / siRNA conjugates in plasma and in tissues.
• Perform high throughput imaging and analysis of cell cultures to assess drug target engagement
• Analyze changes in gene and protein expression from cell cultures, brain and peripheral tissues by RT-qPCR, ELISA
• Develop and troubleshoot assays independently, record, analyze and communicate scientific data.

Basic Qualifications

Additional Skills / Preferences

Lilly is an EEO / Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include : Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

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