Quantitative developer Jobs in Phoenix, AZ

ABOUT CRITICAL PATH INSTITUTE (C-PATH)

Critical Path Institute (C-Path) is a nonprofit engaged in the creation of partnerships and innovative processes that improve human health by reducing the time, cost, and risk in developing and approving new therapies. For over ten years, we have partnered with industry and academic experts to advance technologies across the spectrum of medical product development from research to regulatory approval. As a leading nonprofit organization dedicated to fostering collaboration and promoting data sharing in the precompetitive space, C-Path has been at the forefront of numerous advances designed to get new treatments to patients quicker. Our continuing success is made possible by a combination of public and private support from those who share our vision to accelerate a path to a healthier world.

POSITION OVERVIEW

The Quantitative Medicine (QuantMed) Program at the Critical Path Institute (C-Path) focuses on the development and innovation of quantitative solutions for medical product development and clinical needs. Our team is looking for intellectually curious and innovative thinkers for a position of Quantitative Medicine Scientist. This position's goal is to enhance QuantMed's existing capability in modeling and simulation to support drug development. The Quantitative Medicine Scientist is expected to support QuantMed project deliverables in the areas of pharmacometrics and statistics with focus on neurodegenerative disorders such as Alzheimer's disease. The Quantitative Medicine Scientist will have an opportunity to collaborate with leading subject matter experts and key opinion leaders within C-Path's extensive scientific network.

SUPERVISORY RESPONSIBILITIES

None

CORE DUTIES and RESPONSIBILITIES

• Develop and implement pharmacometrics, statistical, and state of the art quantitative pharmacology approaches to inform drug development for various neurodegenerative disease
• Guide disease progression prediction strategies, incorporating mathematical functions and underlying scientific pathophysiologic principles, in partnership with disease-expert program leads to enable data-driven decisions.
• Evaluate and apply nonlinear mixed effects (NLME) modeling, Bayesian inference, multivariate modeling, causal inference, and other quantitative methodologies as appropriate for drug development decision making.
• Represent the QuantMed Program and provide subject matter expertise on cross‐functional project teams.
• Develop and maintain collaborative working relationship with C-Path colleagues.
• Stay informed about, and devise / apply, new techniques in quantitative medicine, clinical pharmacology, modeling and simulation.
• Author / review / approve modeling and simulation analysis plans and outputs, interpretation, and presentation of key findings to regulators and to stakeholders as needed.
• Write and provide technical input for statistical and pharmacometrics reports and regulatory submissions.
• Ensure adherence to agreed timelines and budgets to insure prompt and accurate execution of deliverables.
• Develop and provide training within and outside the QuantMed Program as needed.

REQUIRED KNOWLEDGE, SKILLS AND ABILITIES

To perform this job successfully, the individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skills, and abilities required. The Quantitative Medicine Scientist must be competent to identify multiple quantitative methods and choose the most appropriate method based on analytic considerations, disease-specific knowledge, and the available data to base the methods on. The individual should be able to communicate effectively in modeling work group calls within C-Path-coordinated public-private-partnerships with external stakeholders. Strong writing skills are needed to contribute effectively to the scientific content of manuscripts, posters, grants, and other external communication documents. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

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REQUIRED EDUCATION and EXPERIENCE

The above statements describe the general nature and level of work only. They are not an exhaustive list of all required responsibilities, duties, and skills. Other duties m ay be added, or this description amended at any time.

Reasonable Accommodation

Newly hired employees in need of an exemption from this policy due to a medical reason or because of a sincerely held religious belief must submit a completed request for accommodation form to the human resources department to begin the interactive accommodation process as soon as possible. Accommodations will be granted where they do not cause C-Path undue hardship or pose a direct threat to the health and safety of others. Please direct any questions regarding this policy to the human resources department.

Critical Path Institute is an equal opportunity employer. Visit our website at

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